UltraGI Replenish™

UltraGI Replenish™ Medical Food is specially formulated to support the nutritional needs of patients with compromised gut function with digestive disorders and malabsorption, and features a key prebiotic designed to support gut microbiome

UltraGI Replenish and the Metagenics Spectrum of Digestive Support

Metagenics provides a complete portfolio of digestive products, and UltraGI Replenish is a part of this portfolio designed to replenish and support the nutritional requirements of patients with compormised gut function.

Key Formula Components and Benefits:

Research-Based Key Ingredients:

  • Proprietary prebiotic fiber blend, including an exclusive nature-identical HMO (as PreBiome 2'-FL)
  • Advanced, clinically tested Sustamine® L-Alanyl-L-Glutamine dipeptide designed for enhanced absoprtion, stability, and solubility to support intestinal health.


  • 20+ essential nutrients for targeted GI support, including:
    • Methylated vitamin B12 and calcium L-5-methyltetrahydrofolate for greater bioavailabilty to address potential malabsoprtion issues.
    • 100% RDI of vitamin D3 to promote absorption and utilization and address potential insufficiencies.
    • Antioxidant nutrients (e.g., vitamins C and E) to protect against oxidative stress.
    • 80% RDI of zinc as zinc gluconate to support mucosal integrity.

Carbohydrate Mix:

  • 17g of carbohydrate, including 7g of fiber and 4g of sugars

Fat Blend:

  • Stragetgic fat blend, including trigycerides (MCTs), flaxseed (containing omega-3 alpha-linolenic acid), and high oleic sunflower oil.

Protein Base:

  • 15g of OptiProtein™ per serving - 12g of pea/rice protein blend and 3g of added essential amino acids to address potential increased needs due to digestive issues and malabsorption.

Restart the Gut with UltraGI Replenish

UltraGI Replenish™ Medical Food is specially formulated to support the increased nutritional needs of patients with compromised gut function and malabsoprtion associated with some of the most challenging digestive disorders.

Designed to restart the gut by restoring a healthy foundation , UltraGI Replenish offers patients a targeted nutritional approach to replenish the intestinal lining and support the beneficial gastrointestinal (GI) microbiota established through early noursihment.

This advanced formula features a key prebiotic, known as 2'-fucosyllactose (2'-FL), that is identical to one found in breast milk. Breakthrough research suggests 2'-FL may be significant to promoting a healthy balance of beneficial GI microbiota.

In addition, this landmark formula features a unique combination of macro- and micronutrients approach unlike nay other.

Healthy Beginnings & New Opportunities

A healthy GI system is the body's first line of defense, yet many common complaints take root in the gut. According to the national Institutes of Health, approximately 70 million people across the US suffer from some type of digestive condition, *which meand 1 out of every 5 people may be affected by GI distrubances.

In addition to genetics, factors such as unhealthy diets, stress, and certain medications may contribute to the development and/or potentiation of compromised epithelial integrity (intestinal permeability) and dysbiosis (unhealthy balance of bacteria) in the small and large intestines. With proper early nourishment and healthy habits maintained into adulthood, many influencers for immune and lifestyle-related digestive disorders may be diminished.

While no one can really start over, nutritionl science is making it easier than ever to give your patients the most pwoerful "gut restart" possible.

A Fresh Start with PreBiome 2'-FL™

For formula optimization, UltraGI Replenish features a prebiotic blend of a nature-identical human milk oligosaccharide (HMO, as PreBiome 2'-FL™) and isomaltoobligosaccharides (IMOs). Prebiotic HMOs and IMOs are non-digestible carbohydrates that act as food for beneficial microbes, including probiotics, and encourage the production of short-chain fatty acids (SCFAs). Many adults with compromised gut function may not obtain enough prebiotic fiber in their diet to support healthy bacteria in the gut and increase the production of SCFAs.

  • 2'-FL is one of the most abundant oligosaccharides in breast milk.
  • HMOs, including 2'-FL, support selective growth of certain bifidobactera to promote a healthy balance of beneficial microbiota.
  • Groundbreaking preliminary research suggests that some HMOs, including 2'-FL, may beneficially influence intestinal recognition processes to help protect against colonization of potentially harmful microorganisms (see Figure1)
  • PreNiome 2'-FL™ is a nature-identical HMO

Figure 1. HMO can serve as decoy receptors to prevent the binding of unwanted microorganisms.

Tender Care with a Bioavailable L-Alanyl-L-Glutamine Dipeptide

Healthy gut function starts with a healthy gut lining. But typical diet may not provide adequate amounts of glutamine in patients with compromised gut function to support the cells that make up the gut lining (known as intestinal epithelial cells). Compromised function of these cells may negatively affect absorption of nutrients.

UltraGI Replenish is formulated with clinically tested L-Alanyl-L-Glutamine dipeptide also known as Sustamine® which helps maintain the integrity of intestinal epithelia cells. This clinically tested glutamine source may also offer an advantage in terms of stability, solubility, and absorption efficiency.
  • Dipeptides are absorbed more efficiently than free amino acids, therefore requiring less energy and promoting faster cell uptake (see Figure 2)
  • In a preliminary clinical stidy, Sustamine® demonstrated greater increases in plasma concentrations of L-Alanyl-L-Glutamine dipeptide when compared to a standard supplemental L-Alanyl-L-Glutamine (see Figure 3)

You can purchase
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Two scoops (40 g) Natural Vanilla Flavor supplies:

Ingredient Amount Daily Value
Calories 150  
Total Fat 5 g  
      Saturated Fat† 1.5 g  
      Trans Fat 0 g  
      Polyunsaturated Fat 1 g  
      Monounsaturated Fat 2 g  
Cholesterol 0 mg  
Sodium 100 mg  
Potassium 220 mg  
Total Carbohydrate 17 mg  
      Dietary Fiber 7 g  
      Sugars 4 g  
Protein 12 g††  

Typical Amino Acid Profile per Serving


740 mg



1080 mg

L-Aspartic Acid 1360 mg  
L-Cystine (Cysteine)*** 150 mg  
L-Glutamic Acid 2050 mg  
L-Glutamine*** 310 mg  
Glycine*** 500 mg  
L-Histidine** 300 mg  
L-Isoleucine (BCAA)** 1070 mg  
L-Leucine (BCAA)** 1820 mg  
L-Lysine** (as L-lysine HCl) 1650 mg  
L-Methionine** 160 mg  
L-Phenylalanine** 670 mg  
L-Proline 550 mg  
L-Serine*** 640 mg  
L-Threonine** 470 mg  
L-Tryptophan** 130 mg  
L-Tyrosine*** 490 mg  
L-Valine (BCAA)** 1190 mg  
Vitamin A (retinyl palmitate) 1250 IU 25%
Vitamin C 100 mg 170%
Calcium 80 mg 8%
Iron 3 mg 15%
Vitamin D3 (as cholecalciferol) 400 IU 100%
Vitamin E 7.5 IU 25%
Thiamin 0.375 mg 25%
Riboflavin 0.425 mg 25%
Niacin 5 mg 25%
Vitamin B6 0.5 mg 25%
Folate (as calcium L-5-methyltetrahydrofolate) 185.2 mcg 45%
Vitamin B12 (as methylcobalamin) 1.5 mcg 25%
Biotin 75 mcg 25%
Pantothenic Acid 2.5 mg 25%
Phosphorus 185 mg 20%
Iodine 37.5 mcg 25%
Magnesium 35 mg 8%
Zinc 11.25 mg 80%
Selenium 52.5 mcg 80%
Copper 1.5 mg 80%
Manganese 1.5 mg 80%
Chromium 120 mcg 100%
Chloride 400 mg 10%
Alpha-Linolenic Acid (ALA) (from flaxseed) 400 mg **
L-Alanyl-L-Glutamine††† 500 mg **
Isomalto-Oligosaccharide 5 g **
2’-Fucosyllactose (2’-FL) 2 g **

Other Ingredients :

Pea protein isolate, isomalto-oligisaccharide, natural flavors, rice protein concentrate, 2’-fucosyllactose powder, flaxseed, organic cane sugar, high oleic sunflower oil, L-lysine HCl, medium chain triglycerides, L-leucine, silica, L-valine, L-alanyl-L-glutamine, L-isoleucine, xanthan gum, vitamin and mineral blend (zinc gluconate, ascorbic acid, manganese gluconate, d-alpha tocopheryl acetate, copper gluconate, D-biotin, retinyl palmitate, niacinamide, cholecalciferol, d-calcium pantothenate, chromium picolinate, pyridoxine HCl, riboflavin, potassium iodide, thiamin HCl, calcium L-5-methyltetrahydrofolate, selenomethionine, and methylcobalamin), and Luo Han Guo fruit (monk fruit) extract.

Storage Statement :
Keep tightly closed in a cool, dry place.

Recommendations :
Blend, shake, or briskly stir 2 level scoops (41 grams) into 8 fluid ounces of chilled water. Take twice daily, or as directed by your healthcare practitioner. Refer to the UltraGI Replenish medical food program guide for easy-to-follow guidelines, tips, recipes, and more.

This medical food has not been studied in children and pregnant or nursing women. If taking medication or other nutritional supplements, consult your healthcare practitioner before use. * Contributed by pea protein, added amino acids, rice protein, Sustamine®, and cocoa powder ** Essential amino acid *** Conditionally essential amino acid † Saturated fat content is contributed by a beneficial form of fat, medium chain triglycerides, which have recognized health benefits. †† 15 g total protein with added amino acids: L-lysine, L-leucine, L-valine, L-isoleucine, and Sustamine® ** Daily value not established †††Sustamine® is a registered trademark of KYOWA HAKKO BIO CO., LTD.

Figure 2: Sustamine® L-Alanyl-L-Glutamine dipeptide is designed to reduce time and energy needed to transport amino acids through cell barriers.
Figure 3: v - up to 224% better absorption than standard L-glutamine

In a preliminary, randomized cross-over design clinical study of 8 healthy men, Sustamine® showed statistically significant increases in both peak and total plasma concentration levels compared to equivalent doses of a standard supplemental L-Alanyl-L-Glutamine, indicating greater transfer from the gut to plasma.

Gentle Nutrition for Those in Need

Patients with compromised gut function are at greater risk of protein-energy malnutrition and potential insufficiencies in essential micronutrients (e.g., vitamin D). During times of distress, they may not be able to consume a "typical" diet and may also benefit from strategic changes in carbohydrate intake, including a diet low in refined sugars and adequate dietary fiber consumption.

UltraGI Replenish represents an unprecedented level of product development and research at Metagenics to deliver a unique combination of ingredients for a truly forward-thinking approach to supporting the specific needs of patients with compromised gut function with digestive disorders including malabsorption.
Focus UltraGI Replenish Advantages
Healthy Microbiome
  • 7g of fiber per servings, primarily comprised of gentle prebiotic fibers:
    • Prebiome 2'-FL designed to promote beneficial microbiota and discourage unwanted microorganisms
    • IMOs to further support colonization of healthy microbiota
    • Both nature-identical HMO and IMOs offer a prebiotic approach for greater digestive comfot.
Intestinal Integrity
  • 11.25 mg per serving of zinc as zinc gluconate
  • Antioxidant nutrients (e.g., vitamins C & E) to help address oxidative stress.
Malabsorption / Nutritional Insufficiencies
  • 185.2 mcg per serving of folate as calcium L-5-methyltetrahydrofolate, a body-ready folate.
  • 1.5 mcg per serving of Vitamin B as methylcobalamin to enhance absorption.
  • 400 IU per serving of vitamin D as vitamin D, the more bioavailable form of vitamin D.
Targeted Nutrition
  • Vegan pea/rice protein blend
    • 15g per serving, including added branched chain amino acids (BCAAs) that may offer an absorption advantage.
  • Strategic blend of omega-3, -6s and -9s(MCTs) - all from plant sources
  • Sweetend with monk fruit extract and a touch of organic cane sugar.



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